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Alzheimer's and family genetic line

2008-08-01T10:39:00.000-07:00

Genetic family factors
When a family member has Alzheimer's disease, many individuals often wonder about their own chances of developing this disease. While heredity is a major factor in a small number of families, for most individuals, genetics plays only a minor role or none at all.

Early-onset
Genetics is most important in families with a history of early-onset Alzheimer's disease (occurring before age 50) stretching back for several generations. (The early-onset form accounts for less than 3% of all Alzheimer's cases in the world today.) Mutations in three genes are known to cause this type of Alzheimer's disease: amyloid precursor protein gene (APP), presenilin 1, and presenilin 2. All three genetic mutations increase the production of beta-amyloid, which is deposited in the plaques found in Alzheimer's disease. APP directs the production of amyloid precursor protein, a brain protein that, when fragmented, sometimes produces beta-amyloid.

If one parent has any of these mutations, each child has a 40 to 50% chance of inheriting the mutated form. A child who inherits the mutated gene will inevitably develop early-onset Alzheimer's disease some time before age 50.

The defective APP gene, found in many families today with early-onset Alzheimer's disease, is located on chromosome 21. People with Down syndrome, a common cause of mental retardation, have an extra copy of this chromosome. This is notable because the similarities between Alzheimer's and Down syndrome are striking close.

People with Down syndrome almost invariably develop Alzheimer's symptoms in middle age between 45 and 60, if they live that long. Tiny amyloid deposits begin showing up in their brains during adolescence, some 20 years before the distinctive tangles and plaques appear. Whether the two disorders are genetically related is unclear, but at least one study found that Alzheimer's patients had a higher than expected number of family members with Down syndrome.

Researchers hope that the discovery of the genetic mutations linked to Alzheimer's disease will shed new light on why the disease causes brain cells to die, and that this understanding will lead to the development of some type of CURE that can protect these cells.

Late-onset
One form (or allele) of a gene that directs the manufacture of a protein called apolipoprotein E (ApoE) has been linked to late-onset Alzheimer's. However, that gene doesn't explain all cases. The ApoE gene is located on chromosome 19 and comes in three alleles: E2, E3, and E4.

Everyone has two genes for ApoE, one inherited from each parent. It's possible to have any one of six combinations — either mixed alleles or a matched pair. The E3 allele is the most common; in fact, more than half the population has a double dose of E3. The relatively rare E2 may provide some protection against Alzheimer's disease. E4, the dangerous variant, is carried by 14% of the U.S. population and by as many as 46% of people with Alzheimer's who have a family history of the disease.

Having one E4 allele increases the risk of developing late-onset Alzheimer's (particularly in people ages 60–70) and lowers the age of onset. Having two E4 alleles strengthens these effects. It's not known exactly how the E4 allele works to increase the risk of developing Alzheimer's, but scientists believe it may play a role in the faulty clearing of beta-amyloid deposits from the brain. In theory, the accumulation of beta-amyloid in the brain sets in motion a series of events that leads to the destruction of nerve cells — but exactly why this abnormal protein is overproduced or not cleared efficiently remains a mystery. ApoE also shuttles cholesterol into and out of cells, and people with E4 are at increased risk of cardiovascular disease.

A pattern of family-based inheritance for late-onset Alzheimer's (age 55 or older) has been difficult to establish, so the chances of inheriting a defective gene are unknown. Having the E4 allele is no guarantee that you will develop the disease, and not having the allele is no guarantee that you won't. The E4 allele is a risk factor for — but not a cause of — late-onset Alzheimer's disease. This lead, while establishing that there is some genetic risk for late-onset Alzheimer's disease, provides no basis for testing the ApoE genotype in healthy individuals without dementia. Mutations on other genes believed to affect the risk of developing late-onset Alzheimer's are also being studied.

Remember there are still no cure for Alzheimer's disease today.

Mary Joseph Foundation a non-profit organization for Alzheimer's disease

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Is it Alzheimer's or early symptoms?

2008-07-22T06:41:00.000-07:00

For physicians and families intent on pinning down a diagnosis, one major factor that complicates the clinical picture is the existence of so many kinds of dementia. More than 100 conditions can mimic or cause dementia. Alzheimer's disease is by far the most common intractable condition. But other causes of irreversible dementia include blood vessel disease (vascular cognitive impairment, Binswanger's dementia), other degenerative disorders (frontotemporal lobar degeneration, Parkinson's disease, Huntington's disease), slow-growing brain tumors, or infections of the central nervous system (Creutzfeldt-Jakob disease, AIDS dementia, neurosyphilis).

In some types of dementia, treatment will improve mental functioning, and in a small percentage, the dementia is completely reversible if treatment begins before permanent brain damage occurs. That's why it is important to report to a doctor any signs of dementia early in the process...Remember if you get Alzheimer's there are no CURE for it.

Early symptoms
Every person is unique and dementia affects people differently - no two people will have symptoms that develop in exactly the same way. An individual's personality, general health and social situation are all important factors in determining the impact of dementia on him or her.

The most common early symptoms of dementia are:

Loss of memory
Declining memory, especially short-term memory, is the most common early symptom of dementia. People with ordinary forgetfulness can still remember other facts associated with the thing they have forgotten. For example they may sometime get lost on their way home by making the wrong turn or briefly forget their next-door neighbor's name but they still know the person they are talking to is their next-door neighbor. A person with dementia will not only forget their neighbor's name but also the context.

Familiar tasks
People with dementia often find it hard to complete everyday tasks that are so familiar we usually do not think about how to do them. A person with dementia may not know in what order to put clothes on or the steps for preparing a meal.

Language
Occasionally everyone has trouble finding the right word but a person with dementia often forgets simple words or substitutes unusual words, making speech or writing hard to understand.

Time and place
We sometimes forget the day of the week or where we are going but people with dementia can become lost in familiar places such as the road they live in, forget where they are or how they got there, and not know how to get back home. For example my mother who made a wrong turn on her way home and end up in a neighbor house, also a person with dementia may also confuse night and day.

Judgment
People with dementia may dress inappropriately, wearing several layers of clothes on a warm day or very few on a cold day, also they may pack food, cloths and shoes together.

Track of things
A person with dementia may find it difficult to follow a conversation or keep up with paying their bills.

Misplacing things
Anyone can temporarily misplace his or her wallet or keys. A person with dementia may put things in unusual places such as an iron in the fridge or a wristwatch in the sugar bowl.

Changes in mood or behavior
Everyone can become sad or moody from time to time. A person with dementia may become unusually emotional and experience rapid mood swings for no apparent reason. Alternatively a person with dementia may show less emotion than was usual previously.

Changes in personality
A person with dementia may seem different from his or her usual self in ways that are difficult to pinpoint. A person may become suspicious, irritable, depressed, apathetic or anxious, angry and agitated especially in situations where memory problems are causing difficulties.

Loss of initiative
At times everyone can become tired of housework, business activities, or social obligations. However a person with dementia may become very passive, sitting in front of the television for hours, sleeping more than usual, or appear to lose interest in hobbies.

If you are experiencing any of these symptoms or are concerned about a friend or relative, visit your doctor and discuss your concerns.

Estelle Getty Born: July 25, 1924 in New York City, New York Occupation: Actor: ... She played Sophia on Golden Girls from 1985 to 1992...We are sorry to hear about Estelle Getty condition, for sometime now she had developed and been living with dementia/Alzheimer's for the pass six years, she die earlier today July 22/08.

Mary Joseph Foundation
137 1/2 Washington Ave.Suite 292
Belleville, New Jersey 07109
form@maryjosephfoundation.org
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Alzheimer's disease and how it affects you and your love ones

2008-06-09T21:50:00.000-07:00

Alzheimer's disease.

Alzheimer's disease affects nearly half of all seniors 78 and older in the world today. It's a particularly cruel disease that affects not only the patients but also their families and others who may depend on them.

One in three Americans knows someone with Alzheimer's.
Alzheimer's strikes one in ten people over age 65 and about half of people over age 78.
Don't let Alzheimer's steal your dreams.

People who have early-onset dementia may be in any stage of dementia – early, middle or late. Experts estimate that some 1.080,000 people in their 30s, 40s and 50s have Alzheimer's disease or a related dementia.

In 2002, Mr.Charlton Heston courageously announced to the public that he was suffering with symptoms consistent with Alzheimer’s disease he was then 78.
In 1994 former president Ronald Reagan said, I have recently been told that I am one of the millions of Americans who will be afflicted with Alzheimer’s disease.

Estelle Getty Born: July 25, 1924 in New York City, New York Occupation: Actor: ... She played Sophia on Golden Girls from 1985 to 1992...We are sorry to hear about Estelle Getty condition, for sometime now she had developed and been living with dementia.

Currently there are over 18 million peoples worldwide who are living with Alzheimer’s disease and that number is expected to grow to as many as 71 million by 2025. Alzheimer’s disease is the seventh leading cause of death in the United States and number six worldwide.

Researchers now identified abnormal tau protein in the entorhinal cortex before dementia was even clinically detectable. For years now most researchers targeted a different symptom, the amyloid beta plaques that gum up the spaces between the brain's neurons, causing them to die.

We are our memories, and almost everything we do is guided by the experiences we have had. All of our skills, our aspirations, our hopes, dreams, and imagination come out of our experiences and the accumulated benefit we have derived from them.
It is that very foundation, however, that turns tremulous for those with Alzheimer's disease
All such memories are an amalgam of associations.

There are still no CURE of any kind for Alzheimer's disease today on the world market... Dr.William Thomas.

We are trying our best to find a cure and at the same time helping individuals who have Alzheimer's disease.

http://www.maryjosephfoundation.blogspot.com
http://www.marycharityfoundation.blogspot.com
http://www.maryjosephfoundation.org

The best security for personal and business computers.

2008-05-27T11:52:00.000-07:00

All donations from any products on our sites are going toward the Alzheimer's relief fund.

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For news and updates.

2008-03-22T12:35:00.000-07:00

Consulting help us to raise funds.

2008-03-22T11:38:00.000-07:00

We dislike ambiguity. If our Consultants and expert speakers in Security, International Law and Constitutions, Security Engineering, Religions and Medicines, can't give you an answer in plain English, then we aren't doing our job. And when a difficult issue arises, in Security, Security Engineering, Politics and Business we lay it out clearly so you know all your options then we get right down and fix the problem .

We know Business and Political Leaders, of course, there's more to business and Politics. That's why we have the best professionals in their fields of Security, Security Engineering, international business investments and tax break, International Law and Constitutions to be business advisors to our Clients. Our clients depend on us for the sort of imaginative business advice that keeps their companies fresh, vital and running.

We know you are busy. That's why we don't spend a lot of extra time in meetings or on the phone. You come to us for essential information and services, and our Security, Security Engineering, international business investment and tax break, International Law and Constitutions and business Consultants give you exactly what you need.

Mary Joseph Foundation
137 1/2 Washington Ave
Suite 292
Belleville, New Jersey 07109

form@maryjosephfoundation.org
http://www.maryjosephfoundation.blogspot.com

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Helping the needy.

2008-03-22T11:34:00.000-07:00

How and why we raise funds.

How and why we raise funds.

The services Mary Joseph Foundation provides to raise funds for individuals who have Alzheimer's disease and young hungry children here and around the world.

( 1 ) We do Consulting and Lecturing on Security, Security, Network and Design Engineering, international business investment and tax break, international Law and Constitutions to Governments and Businesses around the world.

( 2 ) We give talks on Security, Energy, Medicines, Religions, Engineering, international business investment and tax break and Politics.

( 3 ) We develop and sell our products for memory and Brain, to help individuals avoid getting Dementia/Alzheimer's.

To all Governments, Businesses and Universities here in America and around the world, I hope that we at the Mary Joseph Foundation a non-profit organization will get the chance to provide our services to your institutions, now and in the future.
All of our speakers and lecturers are expert in their fields, they are political and fortune 500 corporations leaders from around the world.

Over 90 percent of all funds raise from speaking, consulting and lecturing goes to helping individuals who have Alzheimer's disease and young children who are hungry and some times homeless here in America and in many third world countries. We provides rooming, foods, vitamins, medicines and caring for individuals with Alzheimer's disease especially those who are living in homes for the insane and crazy, on the street and homeless, we also feed young hungry children especially in the third world countries. Mary Joseph Foundation provides all these services for FREE.

Please support us in our non-profit work, there is always a greater happiness in giving than in receiving. We are always looking for partners to work with especially in corporate America and the third world countries.

http://www.maryjosephfoundation.org
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http://www.marycharityfoundation.blogspot.com

Fred Joseph
President
Former senior security engineer Citi Bank, JP Morgan, IBM and the Federal Government.
137 1/2 Washington Ave, Suite 292, Belleville, New Jersey 07109
alzheimers@maryjosephfoundation.org

Helping other's to come together.

2008-03-22T11:32:00.000-07:00

Companies are increasingly looking to pursue cross-border partnerships to augment their global expansion strategies. Large, midsize and small firms alike are scouring the world for partners to bring greater economies, talent and efficiency to their operations. Almost 79% of firms in a worldwide survey of 1000 senior executives conducted by the Economist and marketing Intelligence Unit for MJF plan to increase the number of collaborative relationships they hold with third parties overseas.

Making such relationships work will require the support of new collaborative technologies said Mr. Joseph president of MJF. The survey shows that firms are deploying an entire range of tools to communicate with overseas partners, rating web conferencing and videoconferencing as most useful for helping collaborative relationships succeed in this age of virtualization. They are also experimenting with an array of other technologies—including mobile IP applications and social networking tools—in order to forge better links with their partners.

We can help make things happen fast for you.

Mary Joseph Foundation

All natural organic foods. order ( ID 375220 )

2008-03-22T11:27:00.000-07:00

by: Dr.Williams Thomas.

Mary did this for over fifty years of her life, helping people, especially in third-world countries. Each week she would use her own money to buy foods, medicine, shoes, clothes. and more. She would shop in Newark, Jersey City, and Elizabeth, New Jersey and also in New York. Then every weekend she would pack the boxes and send them off with a smile on her face. Mary had a smile on her face especially when she was packing the boxes to send to those people who did not had anything to eat and were sick. Mary always believed God loved a cheerful giver, so she gave willingly to others. Currently today July 11/2008 there are over 20 million peoples worldwide now and over six million in America who are living with Alzheimer’s disease and that number is expected to grow. We at The Mary Joseph Foundation know by 2050 there would be well over 120 million individuals with Alzheimer's disease worldwide, and about 30 million in America. We are trying our best to find a cure and at the same time helping individuals who have Alzheimer's disease. There are still no CURE of any kind for Alzheimer's disease today on the world market... Dr.Williams Thomas. All funds raise are going toward helping and finding a cure for Alzheimer's disease.

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How can we help you?

2008-03-22T11:25:00.000-07:00

Multi link with peoples and corporations:

All of our services are FREE with a donation's that goes to help individuals who have Alzheimer's disease and hungry and homeless children's...We cares!

Each time anyone order from AT&T on this site will receives $60 from AT&T, and when you order any item from Watkins all natural organic products you will receive FREE gifts from Watkins and at the same time you will be helping the needy...We get a donation from all the ads on our sites that go to help the needy.

Thank for you support

www.maryjosephfoundation.org

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Mary Joseph Foundation

137 1/2 Washington Ave, Suite 292

Belleville, New Jersey 07109

201-336-0075

form@maryjosephfoundation.org

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AT&T Announces Wholesale VOIP Service Expansion worldwide.

At the Fall VON 2007 conference, AT&T Inc. (NYSE:T) today announced the expanded availability of AT&T Voice Over IP Connect Service (AVOICS). AVOICS is the flagship wholesale Voice over Internet Protocol (VoIP) offer for U.S. service providers that want IP-based connectivity to AT&T's global IP network for long distance call termination. For more than 10 years, AT&T has provided wholesale VoIP solutions, which address the U.S. domestic and international termination needs of service providers with a variety of connectivity options.

AVOICS provides unbranded and unbundled transport over the AT&T network, as well as termination of international and U.S. domestic traffic. Customers connect to the service via AT&T's Managed Internet Service (MIS)/Multiprotocol Label Switching-Private Network Transport (MPLS-PNT) service, which provides class-of-service voice quality, key security elements and advanced network reliability. AVOICS is highly scalable and accepts U.S.-originated domestic outbound (1+) calls and international outbound (011+) calls by using Session Initiation Protocol (SIP) signaling.

AT&T has expanded the scale and scope of its wholesale VoIP services, and is now offering AVOICS to customers that want the service with T1, T3 and OCX connectivity as well as meeting a market demand for a customer managed model. Initially introduced with limited availability, AVOICS is now available to all of AT&T's U.S.-based wholesale customers. The expansion of AVOICS specifically includes:

Increased capacity in the VoIP network infrastructure to meet customer traffic demand
Increased connectivity from T1 to T3...all the way to OC48
Moving from an AT&T Managed Router Model to a Customer Managed Router Model to monitor the circuit
Native and non-native IP traffic on the same circuit with unique IP signaling addresses

"AT&T continues to be a significant global player in wholesale VoIP and is enhancing its portfolio to continually meet evolving customer needs," said Cindy Whelan, senior analyst, Business Network Services; Wholesale Services for Current Analysis Inc. "AT&T's experts work closely with customers to customize converged solutions that support their unique VoIP requirements."

AT&T has had more than a decade of wholesale VoIP success already in large part through its pioneer offer, Global Hubbing IP Access (GHIA), which will continue to play a key role in providing service to operators that carry substantial volumes of international traffic. With GHIA, customers send their VoIP traffic to the AT&T network for VoIP termination. If no VoIP termination is available, a Time Division Multiplexing (TDM) conversion is made to cost-effectively deliver calls over AT&T's highly reliable and secure network. AT&T also offers AT&T IP Toll-Free service to wholesale customers for use in their own large call centers, supporting their evolution to the contact center of the future.

"As a world leader in voice and IP networking, AT&T is helping our wholesale customers evolve to the next generation of converged communications through our suite of VoIP services," said Sherry Charles, vice president, Wholesale Marketing, AT&T Operations Inc. "We recognize that our customers need to support both native IP and TDM capabilities. The breadth of VoIP offerings that we supply enable service providers to cost-effectively broaden their footprint and enhance their bandwidth through our robust MPLS-based network with the proven reliability and security that they expect from a global networking leader."

AT&T's suite of wholesale VoIP services connects customers to one of the world's most advanced, secure and powerful global IP backbone networks, lessening the chance for disruption or delays. AT&T's VoIP customers are confident selling services that ride on AT&T's highly reliable network.

As a global leader, AT&T delivers a full portfolio of end-to-end reliable and highly secure network, voice, data and IP solutions to the six wholesale industry segments that it serves: carriers, wireless operators, cable providers, systems integrators, Internet service providers and content providers. AT&T is one of the largest wholesale transport and communications service providers in the world — maintaining connections to more than 400 carriers in more than 220 countries and territories. AT&T brings value to wholesale customers through its global networking, industry-leading portfolio and vertical expertise.

Mary Joseph Foundation

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2008-03-22T11:22:00.000-07:00

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2008-03-22T11:15:00.000-07:00